
TAKEO Satomi
助教
武尾 里美 タケオ サトミ たけお さとみ
プロフィール
最終学歴・学位
東京都立大学大学院理学研究科博士課程・理学博士(2006)
専門・研究分野
遺伝学 発生生物学 生殖生物学 分子生物学
研究
研究テーマ
ショウジョウバエを用いた代謝研究
1)受精卵の代謝プログラム
2)生育環境が代謝プロファイルに与える影響
3)遺伝性代謝疾患モデルの構築
研究キーワード
ショウジョウバエ, 減数分裂, 卵活性化, 受精, 代謝
詳細情報
① 原著論文
Ohnuma K, Kishita, Y, Nyuzuki H, Kohda M., Ohtsu Y, Takeo S, Asano T, Sato-Miyata Y, Ohtake A, Murayama K, Okazaki Y, Aigaki T.
Ski3/TTC37 deficiency associated with trichohepatoenteric syndrome causes mitochondrial dysfunction in Drosophila.
FEBS Lett. 2020 Apr 15. doi: 10.1002/1873-3468.13792
Billmyre KK, Cahoon CK, Heenan GM, Wesley ER, Yu Z, Unruh JR, Takeo S, Hawley RS.
X chromosome and autosomal recombination are differentially sensitive to disruptions in SC maintenance.
Proc Natl Acad Sci U S A. 2019 Oct 22; 116(43): 21641–21650. doi: 10.1073/pnas.1910840116
Hayashi R, Takeo S, Aigaki T.
Sir2 is essential for intergenerational effects of parental diet on offspring metabolism in Drosophila.
bioRxiv. 2019. doi: https://doi.org/10.1101/641076
Quan X, Sato-Miyata Y, Tsuda M, Muramatsu K, Asano T, Takeo S, Aigaki T.
Deficiency of succinyl-CoA synthetase α subunit delays development, impairs locomotor activity and reduces survival under starvation in Drosophila.
Biochem Biophys Res Commun. 2017 Jan 29;483(1):566-571. doi: 10.1016/j.bbrc.2016.12.105
Kaneuchi T, Sartain CV, Takeo S, Horner VL, Buehner NA, Aigaki T, Wolfner MF.
Calcium waves occur as Drosophila oocytes activate.
Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):791-6.
Takeo S, Swanson SK, Nandanan K, Nakai Y, Aigaki T, Washburn MP, Florens L,
Hawley RS.
Shaggy/glycogen synthase kinase 3? and phosphorylation of Sarah/regulator of calcineurin are
essential for completion of Drosophila female meiosis.
Proc. Natl. Acad. Sci. USA. 2012 Apr 24 109(17):6382-6389.
Miller DE, Takeo S, Nandanan K, Paulson A, Gogol MM, Noll AC, Perera AG, Walton KN,
Gilliland WD, Li H, Staehling KK, Blumenstiel JP, Hawley RS.
A whole chromosome analysis of meiotic recombination in Drosophila melanogaster.
Genes, Genomes, Genetics (G3). 2012 Feb 1 2(2):249-260.
Takeo S, Lake CM, Morais-de-Sa E, Sunkel CE, Hawley RS.
Synaptonemal complex-dependent centromeric clustering and the initiation of synapsis in
Drosophila oocytes.
Curr Biol. 2011 Nov 8;21(21):1845-51.
Nakai Y, Horiuchi J, Tsuda M, Takeo S, Akahori S, Matsuo T, Kume K, Aigaki T.
Calcineurin and its regulator Sra/DSCR1 are essential for sleep in Drosophila.
J Neurosci. 2011 Sep 7;31(36):12759-66.
Takeo S, Hawley RS, Aigaki T.
Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila.
Dev Biol. 2010 Aug 15;344(2):957-67.
Hughes SE, Gilliland WD, Cotitta JL, Takeo S, Collins KA, Hawley RS.
Heterochromatic threads connect oscillating chromosomes during prometaphase I in Drosophila
oocytes.
PLoS Genet. 2009 Jan;5(1):e1000348.
Akiyama T, Kamimura K, Firkus C, Takeo S, Shimmi O, Nakato H.
Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface.
Dev Biol. 2008 Jan 1;313(1):408-19.
Xiang Y, Takeo S, Florens L, Hughes SE, Huo LJ, Gilliland WD, Swanson SK, Teeter K,
Schwartz JW, Washburn MP, Jaspersen SL, Hawley RS.
The inhibition of polo kinase by matrimony maintains G2 arrest in the meiotic cell cycle.
PLoS Biol. 2007 Dec;5(12):e323.
Gilliland WD, Hughes SE, Cotitta JL, Takeo S, Xiang Y, Hawley RS.
The multiple roles of Mps1 in Drosophila female meiosis.
PLoS Genet. 2007 Jul 13;3(7):e113.
Takeo S, Tsuda M, Akahori S, Matsuo T, Aigaki T.
The calcineurin regulator sra plays an essential role in female meiosis in Drosophila.
Curr Biol. 2006 Jul 25;16(14):1435-40.
Takeo S, Akiyama T*, Firkus C, Aigaki T, Nakato H.
Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by
affecting action range of Hedgehog.
Dev Biol. 2005 Aug 1;284(1):204-18.
Kotani N, Kitazume S, Kamimura K, Takeo S, Aigaki T, Nakato H, Hashimoto Y.
Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident
transferase, heparan sulfate 6-O-sulfotransferase.
J Biochem (Tokyo). 2005 Mar;137(3):315-22.
Ejima A, Tsuda M, Takeo S, Ishii K, Matsuo T, Aigaki T.
Expression level of sarah, a homolog of DSCR1, is critical for ovulation and female courtship
behavior in Drosophila melanogaster.
Genetics. 2004 Dec;168(4):2077-87.
Takeo S, Fujise M, Akiyama T, Habuchi H, Itano N, Matsuo T, Aigaki T, Kimata K, Nakato H.
In vivo hyaluronan synthesis upon expression of the mammalian hyaluronan synthase gene in
Drosophila.
J Biol Chem. 2004 Apr 30;279(18):18920-5.
Fujise M, Takeo S, Kamimura K, Matsuo T, Aigaki T, Izumi S, Nakato H.
Dally regulates Dpp morphogen gradient formation in the Drosophila wing.
Development. 2003 Apr;130(8):1515-22.
② 総説
Takeo S, Hawley RS.
Rumors of its disassembly have been greatly exaggerated: the secret life of the synaptonemal complex at the centromeres.
PLoS Genet. 2012 Jun;8(6):e1002807.
中藤博志,武尾里美,神村圭亮
第Ⅴ章・モデル生物を用いたヘパラン硫酸プロテオグリカン機能の研究.蛋白質・核酸・酵素増刊号 糖鎖機能 -第3の生命鎖(谷口直之,古川鋼一,鈴木明身,川嵜敏祐、木全弘治編集),共立出版,1072~1078頁,2003.
③ 著書
相垣敏郎,武尾里美
第5章・モデル生物を利用した遺伝子機能解析,ショウジョウバエ.実験医学別冊・ゲノム研究実験ハンドブック(辻本豪三,田中利男,金久實,村松正明編集),羊土社,219~226頁,2004.
Ohnuma K, Kishita, Y, Nyuzuki H, Kohda M., Ohtsu Y, Takeo S, Asano T, Sato-Miyata Y, Ohtake A, Murayama K, Okazaki Y, Aigaki T.
Ski3/TTC37 deficiency associated with trichohepatoenteric syndrome causes mitochondrial dysfunction in Drosophila.
FEBS Lett. 2020 Apr 15. doi: 10.1002/1873-3468.13792
Billmyre KK, Cahoon CK, Heenan GM, Wesley ER, Yu Z, Unruh JR, Takeo S, Hawley RS.
X chromosome and autosomal recombination are differentially sensitive to disruptions in SC maintenance.
Proc Natl Acad Sci U S A. 2019 Oct 22; 116(43): 21641–21650. doi: 10.1073/pnas.1910840116
Hayashi R, Takeo S, Aigaki T.
Sir2 is essential for intergenerational effects of parental diet on offspring metabolism in Drosophila.
bioRxiv. 2019. doi: https://doi.org/10.1101/641076
Quan X, Sato-Miyata Y, Tsuda M, Muramatsu K, Asano T, Takeo S, Aigaki T.
Deficiency of succinyl-CoA synthetase α subunit delays development, impairs locomotor activity and reduces survival under starvation in Drosophila.
Biochem Biophys Res Commun. 2017 Jan 29;483(1):566-571. doi: 10.1016/j.bbrc.2016.12.105
Kaneuchi T, Sartain CV, Takeo S, Horner VL, Buehner NA, Aigaki T, Wolfner MF.
Calcium waves occur as Drosophila oocytes activate.
Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):791-6.
Takeo S, Swanson SK, Nandanan K, Nakai Y, Aigaki T, Washburn MP, Florens L,
Hawley RS.
Shaggy/glycogen synthase kinase 3? and phosphorylation of Sarah/regulator of calcineurin are
essential for completion of Drosophila female meiosis.
Proc. Natl. Acad. Sci. USA. 2012 Apr 24 109(17):6382-6389.
Miller DE, Takeo S, Nandanan K, Paulson A, Gogol MM, Noll AC, Perera AG, Walton KN,
Gilliland WD, Li H, Staehling KK, Blumenstiel JP, Hawley RS.
A whole chromosome analysis of meiotic recombination in Drosophila melanogaster.
Genes, Genomes, Genetics (G3). 2012 Feb 1 2(2):249-260.
Takeo S, Lake CM, Morais-de-Sa E, Sunkel CE, Hawley RS.
Synaptonemal complex-dependent centromeric clustering and the initiation of synapsis in
Drosophila oocytes.
Curr Biol. 2011 Nov 8;21(21):1845-51.
Nakai Y, Horiuchi J, Tsuda M, Takeo S, Akahori S, Matsuo T, Kume K, Aigaki T.
Calcineurin and its regulator Sra/DSCR1 are essential for sleep in Drosophila.
J Neurosci. 2011 Sep 7;31(36):12759-66.
Takeo S, Hawley RS, Aigaki T.
Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila.
Dev Biol. 2010 Aug 15;344(2):957-67.
Hughes SE, Gilliland WD, Cotitta JL, Takeo S, Collins KA, Hawley RS.
Heterochromatic threads connect oscillating chromosomes during prometaphase I in Drosophila
oocytes.
PLoS Genet. 2009 Jan;5(1):e1000348.
Akiyama T, Kamimura K, Firkus C, Takeo S, Shimmi O, Nakato H.
Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface.
Dev Biol. 2008 Jan 1;313(1):408-19.
Xiang Y, Takeo S, Florens L, Hughes SE, Huo LJ, Gilliland WD, Swanson SK, Teeter K,
Schwartz JW, Washburn MP, Jaspersen SL, Hawley RS.
The inhibition of polo kinase by matrimony maintains G2 arrest in the meiotic cell cycle.
PLoS Biol. 2007 Dec;5(12):e323.
Gilliland WD, Hughes SE, Cotitta JL, Takeo S, Xiang Y, Hawley RS.
The multiple roles of Mps1 in Drosophila female meiosis.
PLoS Genet. 2007 Jul 13;3(7):e113.
Takeo S, Tsuda M, Akahori S, Matsuo T, Aigaki T.
The calcineurin regulator sra plays an essential role in female meiosis in Drosophila.
Curr Biol. 2006 Jul 25;16(14):1435-40.
Takeo S, Akiyama T*, Firkus C, Aigaki T, Nakato H.
Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by
affecting action range of Hedgehog.
Dev Biol. 2005 Aug 1;284(1):204-18.
Kotani N, Kitazume S, Kamimura K, Takeo S, Aigaki T, Nakato H, Hashimoto Y.
Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident
transferase, heparan sulfate 6-O-sulfotransferase.
J Biochem (Tokyo). 2005 Mar;137(3):315-22.
Ejima A, Tsuda M, Takeo S, Ishii K, Matsuo T, Aigaki T.
Expression level of sarah, a homolog of DSCR1, is critical for ovulation and female courtship
behavior in Drosophila melanogaster.
Genetics. 2004 Dec;168(4):2077-87.
Takeo S, Fujise M, Akiyama T, Habuchi H, Itano N, Matsuo T, Aigaki T, Kimata K, Nakato H.
In vivo hyaluronan synthesis upon expression of the mammalian hyaluronan synthase gene in
Drosophila.
J Biol Chem. 2004 Apr 30;279(18):18920-5.
Fujise M, Takeo S, Kamimura K, Matsuo T, Aigaki T, Izumi S, Nakato H.
Dally regulates Dpp morphogen gradient formation in the Drosophila wing.
Development. 2003 Apr;130(8):1515-22.
② 総説
Takeo S, Hawley RS.
Rumors of its disassembly have been greatly exaggerated: the secret life of the synaptonemal complex at the centromeres.
PLoS Genet. 2012 Jun;8(6):e1002807.
中藤博志,武尾里美,神村圭亮
第Ⅴ章・モデル生物を用いたヘパラン硫酸プロテオグリカン機能の研究.蛋白質・核酸・酵素増刊号 糖鎖機能 -第3の生命鎖(谷口直之,古川鋼一,鈴木明身,川嵜敏祐、木全弘治編集),共立出版,1072~1078頁,2003.
③ 著書
相垣敏郎,武尾里美
第5章・モデル生物を利用した遺伝子機能解析,ショウジョウバエ.実験医学別冊・ゲノム研究実験ハンドブック(辻本豪三,田中利男,金久實,村松正明編集),羊土社,219~226頁,2004.
日本分子生物学会
- 遺伝学実験(細胞遺伝)
- 生物学英語演習
- 生命科学セミナー1(細胞遺伝1)
- 生命科学セミナー1(細胞遺伝1)
- 生命科学セミナー2(細胞遺伝1)
- 生命科学セミナー2(細胞遺伝1)
- 生命科学セミナー1(細胞遺伝2)
- 生命科学セミナー1(細胞遺伝2)
- 生命科学セミナー2(細胞遺伝2)
- 生命科学セミナー2(細胞遺伝2)
- 生命科学実験1(細胞遺伝)
- 生命科学実験1(細胞遺伝)
- 生命科学実験2(細胞遺伝)
- 生命科学実験2(細胞遺伝)
- 組織再編前旧課程の同時開講科目等が含まれており、掲載されている全ての科目を開講するわけではありません。
連絡先
研究室
8号館441号室
内線番号
内線3745
メールアドレス
takeo-satomi●tmu.ac.jp
(メールを送信される場合は●を@に変換してください)