KAWASUMI Ryotaro
助教
川澄 遼太郎 カワスミ リョウタロウ かわすみ りょうたろう
プロフィール
最終学歴・学位
The Open University, School of Life, Health, and Chemical Science, Ph.D.
専門・研究分野
生物化学
研究
研究テーマ
ゲノム安定性維持機構に関する研究
研究キーワード
DNA複製、DNA修復、染色体分配、核酸類似化合物、抗がん剤、コヒーシン
詳細情報
1. Washif M, Kawasumi R, Hirota K. PrimPol-mediated repriming elicits gap-filling by template switching and promotes cellular tolerance to Cidofovir. DNA Repair (Amst). 2024 Nov;(103787):103787.
2. Rahman R, Kawasumi R, Hirota K. The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir. DNA Repair (Amst). 2024 Oct;(103773):103773.
3. Ahmad T, Kawasumi R (共筆頭著者), Hirota K. RAD18‐ and BRCA1‐dependent pathways promote cellular tolerance to the nucleoside analog ganciclovir. Genes Cells [Internet]. 2024 Aug 22; Available from: https://pubmed.ncbi.nlm.nih.gov/39169841/
4. Washif M, Kawasumi R (共筆頭著者), Hirota K. REV3 promotes cellular tolerance to 5-fluorodeoxyuridine by activating translesion DNA synthesis and intra-S checkpoint. PLoS Genet. 2024 Jul;20(7):e1011341.
5. Kojima K, Ohkubo H, Kawasumi R, Hirota K. Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates. DNA Repair . 2024 Apr 24;139:103688.
6. Hosen MB, Kawasumi R (共筆頭著者), Hirota K. Dominant roles of BRCA1 in cellular tolerance to a chain-terminating nucleoside analog, alovudine. DNA Repair . 2024 Mar 5;137:103668.
7. Rahman MR, Hirota K, Kawasumi R (共責任著者). Proofreading exonuclease activity of replicative polymerase epsilon promotes cellular tolerance to arabinosides in CTF18-dependent and -independent manner. Genome Instability & Disease [Internet]. 2024 Apr 1; Available from: https://doi.org/10.1007/s42764-024-00124-w
8. Ahmad T, Kawasumi R (共筆頭著者), Taniguchi T, Abe T, Terada K, Tsuda M, et al. The proofreading exonuclease of leading-strand DNA polymerase epsilon prevents replication fork collapse at broken template strands. Nucleic Acids Res [Internet]. 2023 Nov 8; Available from: http://dx.doi.org/10.1093/nar/gkad999
9. Psakhye I, Kawasumi R (共筆頭著者), Abe T, Hirota K, Branzei D. PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion. Nat Struct Mol Biol. 2023 Aug 17;1–9.
10. Washif M, Ahmad T, Hosen MB, Rahman MR, Taniguchi T, Okubo H, Hirota K, Kawasumi R (共責任著者). CTF18-RFC contributes to cellular tolerance against chain-terminating nucleoside analogs (CTNAs) in cooperation with proofreading exonuclease activity of DNA polymerase ε. DNA Repair . 2023 Jul 1;127:103503.
11. Kawasumi R (共筆頭著者), Abe T, Psakhye I, Miyata K, Hirota K, Branzei D. Vertebrate CTF18 and DDX11 essential function in cohesion is bypassed by preventing WAPL-mediated cohesin release. Genes Dev. 2021 Oct 1;35(19–20):1368–82.
12. Rossi F, Helbling-Leclerc A, Kawasumi R, Jegadesan NK, Xu X, Devulder P, et al. SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability. EMBO Rep. 2020 Feb 5;21(2):e48222.
13. Abe T, Ooka M, Kawasumi R, Miyata K, Takata M, Hirota K, et al. Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8412–7.
14. Abe T, Kawasumi R (共筆頭著者), Giannattasio M, Dusi S, Yoshimoto Y, Miyata K, et al. AND-1 fork protection function prevents fork resection and is essential for proliferation. Nat Commun. 2018 Aug 6;9(1):3091.
15. Kawasumi R (共筆頭著者), Abe T, Arakawa H, Garre M, Hirota K, Branzei D. ESCO1/2’s roles in chromosome structure and interphase chromatin organization. Genes Dev. 2017 Nov 1;31(21):2136–50.
16. Abe T, Kawasumi R, Arakawa H, Hori T, Shirahige K, Losada A, et al. Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion. Oncotarget. 2016 Oct 18;7(42):67934–47.
2. Rahman R, Kawasumi R, Hirota K. The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir. DNA Repair (Amst). 2024 Oct;(103773):103773.
3. Ahmad T, Kawasumi R (共筆頭著者), Hirota K. RAD18‐ and BRCA1‐dependent pathways promote cellular tolerance to the nucleoside analog ganciclovir. Genes Cells [Internet]. 2024 Aug 22; Available from: https://pubmed.ncbi.nlm.nih.gov/39169841/
4. Washif M, Kawasumi R (共筆頭著者), Hirota K. REV3 promotes cellular tolerance to 5-fluorodeoxyuridine by activating translesion DNA synthesis and intra-S checkpoint. PLoS Genet. 2024 Jul;20(7):e1011341.
5. Kojima K, Ohkubo H, Kawasumi R, Hirota K. Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates. DNA Repair . 2024 Apr 24;139:103688.
6. Hosen MB, Kawasumi R (共筆頭著者), Hirota K. Dominant roles of BRCA1 in cellular tolerance to a chain-terminating nucleoside analog, alovudine. DNA Repair . 2024 Mar 5;137:103668.
7. Rahman MR, Hirota K, Kawasumi R (共責任著者). Proofreading exonuclease activity of replicative polymerase epsilon promotes cellular tolerance to arabinosides in CTF18-dependent and -independent manner. Genome Instability & Disease [Internet]. 2024 Apr 1; Available from: https://doi.org/10.1007/s42764-024-00124-w
8. Ahmad T, Kawasumi R (共筆頭著者), Taniguchi T, Abe T, Terada K, Tsuda M, et al. The proofreading exonuclease of leading-strand DNA polymerase epsilon prevents replication fork collapse at broken template strands. Nucleic Acids Res [Internet]. 2023 Nov 8; Available from: http://dx.doi.org/10.1093/nar/gkad999
9. Psakhye I, Kawasumi R (共筆頭著者), Abe T, Hirota K, Branzei D. PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion. Nat Struct Mol Biol. 2023 Aug 17;1–9.
10. Washif M, Ahmad T, Hosen MB, Rahman MR, Taniguchi T, Okubo H, Hirota K, Kawasumi R (共責任著者). CTF18-RFC contributes to cellular tolerance against chain-terminating nucleoside analogs (CTNAs) in cooperation with proofreading exonuclease activity of DNA polymerase ε. DNA Repair . 2023 Jul 1;127:103503.
11. Kawasumi R (共筆頭著者), Abe T, Psakhye I, Miyata K, Hirota K, Branzei D. Vertebrate CTF18 and DDX11 essential function in cohesion is bypassed by preventing WAPL-mediated cohesin release. Genes Dev. 2021 Oct 1;35(19–20):1368–82.
12. Rossi F, Helbling-Leclerc A, Kawasumi R, Jegadesan NK, Xu X, Devulder P, et al. SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability. EMBO Rep. 2020 Feb 5;21(2):e48222.
13. Abe T, Ooka M, Kawasumi R, Miyata K, Takata M, Hirota K, et al. Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8412–7.
14. Abe T, Kawasumi R (共筆頭著者), Giannattasio M, Dusi S, Yoshimoto Y, Miyata K, et al. AND-1 fork protection function prevents fork resection and is essential for proliferation. Nat Commun. 2018 Aug 6;9(1):3091.
15. Kawasumi R (共筆頭著者), Abe T, Arakawa H, Garre M, Hirota K, Branzei D. ESCO1/2’s roles in chromosome structure and interphase chromatin organization. Genes Dev. 2017 Nov 1;31(21):2136–50.
16. Abe T, Kawasumi R, Arakawa H, Hori T, Shirahige K, Losada A, et al. Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion. Oncotarget. 2016 Oct 18;7(42):67934–47.
日本分子生物学会、3R3C学会、SMCタンパク質学会
連絡先
研究室
9号館415室
オフィスアワー
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