My research has focused on the design of photoresponsive molecules, supramolecular systems, and functional nanomaterials with applications in chirality control, drug delivery, and photopharmacology. During my Ph.D. at Hokkaido University under Prof. Nobuyuki Tamaoki (2009–2012), I developed azobenzene-based prochiral molecules to investigate the origin of homochirality. I demonstrated light-induced chirality generation using both polarized and non-polarized light, and proposed a new mechanism involving ground-state chiral discrimination (Chem. Eur. J. 2011). I further showed that point, planar, and axial chirality can be generated by molecular design and photoirradiation (Angew. Chem. 2011; Chem. Sci. 2015; ChemPhotoChem 2020). As a postdoctoral researcher with Prof. Takuzo Aida at the University of Tokyo (2012–2017), I developed template-assisted oxidative polymerization to fabricate protective polymer nanocapsules for siRNA delivery (J. Am. Chem. Soc. 2015). This platform enabled intracellular delivery of nucleic acids and proteins, and was extended to targeted tumor penetration systems. I later reviewed this concept for sub-100 nm drug delivery systems (Nanoscale Horizons 2024). From 2017 to 2021, I expanded into collaborative nanobiotechnology research. I contributed to the development of RNA-driven supramolecular polymerization of chaperonin GroEL for ATP-responsive drug delivery, achieving efficient cellular uptake and gene knockdown in tumor models. I also developed nanoparticle–protein hybrid frameworks with hierarchical porous structures while retaining protein functionality (Angew. Chem. 2023). From 2021-2026, as an assistant professor at Hokkaido University, I have focused on visible-light-responsive photoswitches for photopharmacology. I developed azothiazole-based switches with red-shifted absorption and tunable properties (J. Am. Chem. Soc. 2023), and introduced machine learning approaches for predicting photophysical behavior. I also discovered an unusual cis-state oligomerization in fluorinated phenylazothiazoles (Chem. Eur. J. 2024), and identified unexpected enzymatic activity of GroEL toward small-molecule substrates (Org. Biomol. Chem. 2023).
1. J. Qi, A.S. Amrutha, S. Ishida-Ishihara, H. Dokainish, P. K. Hashim, R. Miyazaki, M. Tsuda, S. Tanaka, N. Tamaoki.* Caging Bioactive Triarylimidazoles: An Approach to Create Visible Light-Activatable Drugs. J. Am. Chem. Soc.,(2024), 146, 26, 18002.
2. P. K. Hashim*, P. P. Naseef, M.C. Nusaiba, S.K. Mohamed. Drug delivery systems for Natural Medicines in cancer therapy. Curr. Top. Med. Chem. (2024), in press
3. P. K. Hashim*, S.M. Abdrabou. Sub-100 nm carriers by template polymerization for drug delivery applications. Nanoscale Horiz., (2024), 9, 693-707.
4. P. K. Hashim,* S. Sahu, K. Takahashi, T. Shakkeeb, T. Nakamura, and N. Tamaoki. Geometry-induced oligomerization of fluorine-substituted phenylazothiazole photoswitches. Chem. Eur. J. (2024), e202400047.
5. P. K. Hashim*, H. M Dokainish and N. Tamaoki. Chaperonin GroEL hydrolyses ortho-nitrophenyl β-galactoside. Org. Biomol. Chem., (2023), 21, 6120.
6. R. Lin, P. K. Hashim (co-first author), S. Sahu, A. S. Amrutha, Nusaiba M.C., T. Shakkeeb, K. Takahashi, T. Nakamura, T. Kikukawa, and N. Tamaoki. Phenylazothiazoles as Visible-Light Photoswitches. J. Am. Chem. Soc.,(2023), 145, 16, 9072.
7. H. K. Shen, K. Morishita, P. K. Hashim, K. Okuro, D. Kashiwagi, A. Kimura, H. Yanagisawa, M. Kikkawa, T. Niwa, H. Taguchi, T. Aida, ATP-Responsive Nanoparticles Covered with Biomolecular Machine “Chaperonin GroEL” Angew. Chem. Int. Ed. (2023), e202304894.
8. S. Thayyil, Y. Nishigami, M.J. Islam, P. K Hashim, K Furuta, K Oiwa, J. Yu, M. Yao, T. Nakagaki, N. Tamaoki. Dynamic control of microbial movement by photoswitchable ATP antagonists. Chem. Eur. J. (2022), e202200807.
9. P. K Hashim*. Genomic medicine: Ultra-small Nanocaplets for drug delivery applications. Journal of the Japanese Society of Nucleic Acid Chemistry Vol.5 (2021 November).
10. Ai Kohata, Ryosuke Ueki, Kou Okuro, P. K. Hashim, Shinsuke Sando and Takuzo Aida. Photoreactive Molecular Glue for Enhancing the Efficacy of DNA Aptamers by Temporary-to-Permanent Conjugation with Target Proteins J. Am. Chem. Soc., 143 (2021), 13937.
11. P. K. Hashim, Julian Bergueiro, E.W Meijer and Takuzo Aida. Supramolecular Polymerization: A Conceptual Expansion for Innovative Materials. Prog. Polym. Sci 105 (2020), 101250.
12. P. K Hashim and Nobuyuki Tamaoki. Enantioselective Photochromism under Circularly Polarized Light. ChemPhotoChem, 3 (2019), 347–355.
13. Ai Kohata, P. K. Hashim, Kou Okuro and Takuzo Aida. Transferrin appended Nanocaplet for transcellular siRNA delivery into deep tissues. J. Am. Chem. Soc., 141 (2019), 2862–2866.
14. Rina Mogaki P. K. Hashim, Kou Okuro and Takuzo Aida. Molecular Glues for Modulation of Biomolecular Functions. Chem. Soc. Rev, 46 (2017), 6480.
15. P. K. Hashim, Kou Okuro, Takuzo Aida. Ultra-small, glutathione responsive nanocaplets prepared via templated-polymerization for gene and protein delivery. J. Control. Release. 259 (2017) e5–e195, DOI: 10.1016/j.jconrel.2017.03.214
16. P. K. Hashim, Kou Okuro, Shigekazu Sasaki, Yatsuka Hoashi, Takuzo Aida Reductively Cleavable Nanocaplets for siRNA Delivery by Template-Assisted Oxidative polymerization. J. Am. Chem. Soc., 137 (2015) 15608.
17. K Rijeesh, P. K. Hashim, Shin-ichiro Noro, Nobuyuki Tamaoki. Dynamic Induction of Enantiomeric Excess from a Prochiral Azobenzene Dimer Under Circularly Polarized Light.
Chem. Sci, 6 (2015) 973. 

18. P. K. Hashim, Meethale C. Basheer, Nobuyuki Tamaoki. Chirality induction by E/Z photoisomerization in [2, 2]paracyclophane-bridged 
azobenzene dimer
 
Tetrahedron Letters, 54 (2013) 176. 

19. P. K. Hashim and Nobuyuki Tamaoki. Induction of Point Chirality by E/Z Photoisomerization. Angew. Chem. Int. Ed. 50 (2011), 11729.
Highlighted in Nature Chemistry, 4, 5, 2012. ChemViews.16, November 2011.
20. P. K. Hashim, Reji Thomas and Nobuyuki Tamaoki. Induction of Molecular Chirality by Circularly Polarized Light in Cyclic Azobenzene with a Photoswitchable Benzene rotor. Chem. Eur. J. 17 (2011), 7304.
21. P. K. Hashim. Genomic Medicine: Ultra-small siRNA-caplet for Delivery Application, ISAJ Newsletter, September 2016.

 Young scientist award (2017, Gordon Research Conference, Switzerland)
 CSJ presentation award (2019, Annual meeting of the chemical society of Japan)
 Otsuka award (2019, International symposium on nucleic acid chemistry, Japan)
 Chemical Science, Nanoscale Advances, Nanoscale Horizons and Nanoscale outstanding oral presentation prize at ANNIC 2021 (2021, Royal Society of Chemistry)
 8th Interdepartmental Symposium Research Grant Silver Award 2022 (Hokkaido University, Japan)
 9th Interdepartmental Symposium Research Grant Silver Award 2023 (Hokkaido University, Japan)

Invited talks in the scientific symposiums/conferences (years 2019–2024)
1. Photopharmacology; fundamentals and applications. DAILAB-CAFÉ international seminar by National Institute of Advanced Industrial Science & Technology (AIST), June 24, 2024, Tsukuba, Japan,
2. Nanoparticle protein framework hybrid materials. International conference on advanced materials for sustainability (ICAMS), Dec 21-23, 2023, Kerala, India.
3. Nanoparticle functionalized with Biomolecular Machine. India-Japan symposium on Interdisciplinary S&T Innovations for Sustainable World. November 26-27, 2021, Shizuoka, Japan.
4. RNA driven supramolecular polymerization of chaperonin GroEL for ATP responsive delivery application, First Aida-Meijer joint symposium on Molecular Assembly, Supramolecular Polymerization, and Materials Science. January 14, 2021, Tokyo

Services
(a) Membership of Professional Bodies
 The Chemical Society of Japan (CSJ), Member, 2015-present
 The Japanese photochemistry association, Japan, Member, 2021-present
 Indian Scientist Association Japan (ISAJ), Japan, 2010-present, executive member
 India Japan Society for Science, Technology and Education (IJSSTE). Executive, 2024
(b) Conference Committees
 Chair; 14th ISAJ symposium on Integrated science for a sustainable society, 2023, Hokkaido University, Japan (~100 attendee)
 Co-chair; 8th ISAJ symposium on bridging science and technology, 2017, The University of Tokyo, Japan (~100 attendee)
 Co-chair; 7th ISAJ symposium on bridging science and technology, 2016, Indian Embassy Tokyo, Japan (~120 attendee).
 Chair; 8th JMRIS symposium on interdisciplinary sciences, 2015, The University of Tokyo, Japan (~60 attendee)

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• 先端物質デザイン化学講究Ⅱ

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