Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex
Nguyen TP, Otani T, Tsutsumi M, Kinoshita, N, Fujiwara S, Nemoto T, Fujimori T, Furuse M.
J Cell Biol. 2024; 223(5): e202307104. doi:10.1083/jcb.202307104.

Effective mechanical potential of cell-cell interaction in tissues harboring cavity and in cell sheet toward morphogenesis
Koyama H, Okumura H, Otani T, Ito AM, Nakamura K, Kato K, Fujimori T.
bioRxiv, 2023; 2023.08. 28.555208. doi: 10.1101/2023.08.28.555208.

Effective mechanical potential of cell-cell interaction explains three-dimensional morphologies during early embryogenesis.
Koyama H, Okumura H, Ito AM, Nakamura K, Otani T, Kato K, Fujimori T.
PLoS Comput Biol. 2023;19(8):e1011306. doi: 10.1371/journal.pcbi.1011306.

Mechanism of interdigitation formation at apical boundary of MDCK cell.
Miyazaki S, Otani T, Sugihara K, Fujimori T, Furuse M, Miura T.
iScience. 2023;26(5):106594. doi: 10.1016/j.isci.2023.106594.

ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions.
Haas AJ, Zihni C, Krug SM, Maraspini R, Otani T, Furuse M, Honigmann A, Balda MS, Matter K.
Cells. 2022;11(23):3775. doi: 10.3390/cells11233775.

Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif.
Fujiwara S, Nguyen TP, Furuse K, Fukazawa Y, Otani T, Furuse M.
Ann N Y Acad Sci. 2022;1516(1):85-94. doi: 10.1111/nyas.14881.

Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes.
Ciesielski HM, Nishida H, Takano T, Fukuhara A, Otani T, Ikegawa Y, Okada M, Nishimura T, Furuse M, Yoo SK.
PLoS Biol. 2022;20(4):e3001586. doi: 10.1371/journal.pbio.3001586.

JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells.
Thölmann S, Seebach J, Otani T, Florin L, Schnittler H, Gerke V, Furuse M, Ebnet K.
Cell Mol Life Sci. 2022;79(2):88. doi: 10.1007/s00018-022-04140-5.

Angulin-1 seals tricellular contacts independently of tricellulin and claudins.
Sugawara T, Furuse K, Otani T, Wakayama T, Furuse M.
J Cell Biol. 2021;220(9):e202005062. doi: 10.1083/jcb.202005062.

Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function.
Saito AC, Higashi T, Fukazawa Y, Otani T, Tauchi M, Higashi AY, Furuse M, Chiba H.
Mol Biol Cell. 2021;32(8):722-738. doi: 10.1091/mbc.E20-07-0464.

Tight Junction Structure and Function Revisited.
Otani T, Furuse M.
Trends Cell Biol. 2020;30(10):805-817. doi: 10.1016/j.tcb.2020.08.004.

Physiological functions of junctional adhesion molecules (JAMs) in tight junctions.
Hartmann C, Schwietzer YA, Otani T, Furuse M, Ebnet K.
Biochim Biophys Acta Biomembr. 2020;1862(9):183299. doi: 10.1016/j.bbamem.2020.183299.

The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts.
Oda Y, Sugawara T, Fukata Y, Izumi Y, Otani T, Higashi T, Fukata M, Furuse M.
J Biol Chem. 2020;295(13):4289-4302. doi: 10.1074/jbc.RA119.010491.

Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity.
Otani T, Nguyen TP, Tokuda S, Sugihara K, Sugawara T, Furuse K, Miura T, Ebnet K, Furuse M.
J Cell Biol. 2019;218(10):3372-3396. doi: 10.1083/jcb.201812157.

The plus-tip tracking and microtubule stabilizing activities of Javelin-like regulate microtubule organization and cell polarity.
Baskar R, Bahkrat A, Otani T, Wada H, Davidov G, Pandey H, Gheber L, Zarivach R, Hayashi S, Abdu U.
FEBS J. 2019;286(19):3811-3830. doi: 10.1111/febs.14944.

IKKε inhibits PKC to promote Fascin-dependent actin bundling.
Otani T, Ogura Y, Misaki K, Maeda T, Kimpara A, Yonemura S, Hayashi S.
Development. 2016;143(20):3806-3816. doi: 10.1242/dev.138495.

A transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation.
Otani T, Oshima K, Kimpara A, Takeda M, Abdu U, Hayashi S.
Development. 2015;142(13):2338-51. doi: 10.1242/dev.121863.

Tricellulin regulates junctional tension of epithelial cells at tricellular contacts through Cdc42.
Oda Y, Otani T, Ikenouchi J, Furuse M.
J Cell Sci. 2014;127(19):4201-12. doi: 10.1242/jcs.150607.

Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like.
Amsalem S, Bakrhat A, Otani T, Hayashi S, Goldstein B, Abdu U.
Mol Cell Biol. 2013;33(22):4371-80. doi: 10.1128/MCB.00713-13.

Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control.
Dong B, Kakihara K, Otani T, Wada H, Hayashi S.
Nat Commun. 2013;4:1358. doi: 10.1038/ncomms2347.

Rab11-FIP3 is a cell cycle-regulated phosphoprotein.
Collins LL, Simon G, Matheson J, Wu C, Miller MC, Otani T, Yu X, Hayashi S, Prekeris R, Gould GW.
BMC Cell Biol. 2012;13:4. doi: 10.1186/1471-2121-13-4.

IKKε regulates cell elongation through recycling endosome shuttling.
Otani T, Oshima K, Onishi S, Takeda M, Shinmyozu K, Yonemura S, Hayashi S.
Dev Cell. 2011;20(2):219-32. doi: 10.1016/j.devcel.2011.02.001.

Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells.
Otani T, Ichii T, Aono S, Takeichi M.
J Cell Biol. 2006;175(1):135-46. doi: 10.1083/jcb.200605012.

日本分子生物学会
日本発生生物学会
日本細胞生物学会

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• 生命科学セミナー1（細胞生化学2）
• 生命科学セミナー2（細胞生化学2）
• 生命科学セミナー2（細胞生化学2）
• 生命科学実験1（細胞生化学）
• 生命科学実験1（細胞生化学）
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