IKEYA Teppei

池谷 鉄兵 イケヤ テッペイ いけや てっぺい



東京都立大学理学部 化学科
理学研究科 化学専攻


東京大学大学院 農学生命科学研究科 応用生命工学専攻 博士(農学)





(1) NMR蛋白質立体構造計算法の開発
(2) NMRスペクトル再構成法の開発




論文リスト(2009~ 抜粋)
*責任著者, ※co-first author

1. Okada, M., Tateishia, Y., Nojiri, E., Mikawa, T., Rajesh, S., Ogasa, H., Ueda, T., Yagi, H., Kohno, T., Kigawa, T., Shimada, I., Güntert, P., *Ito, Y., & *Ikeya, T., Multi-state structure determination and dynamics analysis reveals a new ubiquitin-recognition mechanism in yeast ubiquitin C-terminal hydrolase, biorxiv 2021.04.22.440356 (2021)

2. *Ikeya, T., Güntert, P., & *Ito, Y., Protein Structure Determination in Living Cells, Int. J. Mol. Sci. 20(10), 2442 (2019)

3. Wakamoto, T., Ikeya, T., Kitazawa, S., Baxter, S.J., Williamson, M.P., & *Kitahara, R., Paramagnetic relaxation enhancement-assisted structural determination of a partially disordered conformation of ubiquitin, Protein Sci. 28(11),1993-2003 (2019)

4. ※Tanaka*, ※, *Ikeya, T., Kamoshida, H., Mishima, M., Shirakawa, M., Güntert, P., & *Ito, Y., High resolution protein 3D structure determination in living eukaryotic cells, Angew. Chem. Int. Ed., 58 (22), 7284-7288 (2019)

5. *Ikeya, T., Ban, D., Lee, D., Ito, Y., Kato, K., & *Griesinger, C., Solution NMR views of dynamical ordering of biomacromolecules, Biochim. Biophys. Acta, Gen. Subj., 1862 (2) 287-306 (2018)

6. *Ikeya, T., & Ito, Y., Protein NMR structure refinement based on Bayesian Inference for dynamical ordering of biomacromolecules, J. Comput. Chem. Jpn., 7 (1), 65-75 (2018)

7. *Ikeya, T., Hanashima, T., Hosoya, S., Shimazaki, M., Ikeda, S., Mishima, M., Güntert, P. & *Ito, Y. Improved in-cell structure determination of proteins at near-physiological concentration., Sci. Rep. 6, 38312:1-11 (2016)

8. Hikone, Y., Hirai, G., Mishima, M., Inomata, K., Ikeya, T., Arai, S., Shirakawa, M., Sodeoka, M., &*Ito, Y., A new carbamidemethyl-linked lanthanide chelating tag for PCS NMR spectroscopy of proteins in living HeLa cells, J. Biomol. NMR. 66 (2), 99-110 (2016)

9. *Ikeya, T., Ikeda, S., Kigawa, T., Ito, Y. & *Güntert, P., A Protein NMR Structure Refinement based on Bayesian Inference, J. Phys. Conf. Ser. 699, 012003 (2016)

10. Nishida, Y., Ikeya, T., Mikawa, T., Inoue, J., Ito, Y., Shintani, Y., Masui, R., Kuramitsu, S. & *Takashima, S., A specific single-stranded DNA induces a distinct conformational change in the nucleoid-associated protein HU, Biochem. Biophys. Rep. 8, 318-324 (2016)

11. Kasai, T., Ikeya, T., *Kigawa, T., Application of Sparse Modeling to Biological NMR, J. IEICE, 99, 5, 439-443 (2016)

12. Shigemitsu, Y., Ikeya, T., Yamamoto, A., Tsuchie, Y., Mishima, M., Smith, B. O., Güntert, P. & *Ito, Y. Evaluation of the reliability of the maximum entropy method for reconstructing 3D and 4D NOESY-type NMR spectra of proteins. Biochem. Biophys. Res. Commun. 457, 200-205 (2015)

13. Lin, Y. J., Ikeya, T., Kirchner, D. K. & *Güntert, P., Influence of incomplete NOESY peaks of the interface residues on structure determinations of homodimeric proteins., J. Chin. Chem. Soc. 61, 1297-1306 (2014)

14. Schmidt, E., Ikeya, T., Takeda, M., Löhr, F., Buchner, L., Ito, Y., Kainosho, M., *Güntert, P., Automated resonance assignment of the 21 kDa stereo-array isotope labeled thioldisulfide oxidoreductase DsbA., J. Magn. Reson. 249, 88-93 (2014)

15. Hembram, D.S., Haremaki, T., Hamatsu, J., Inoue, J., Kamoshida, H., Ikeya, T., Mishima, M., Mikawa, T., Hayashi, N., Shirakawa, M. & *Ito, Y., An in-cell NMR study of monitoring stress-induced increase of cytosolic Ca2+ concentration in HeLa cells., Biochem. Biophys. Res. Commun. 438, 653-659 (2013)

16. Lin, Y. J., Ikeya, T., Güntert, P. & *Chang, L. S., NMR solution structure of a chymotrypsin inhibitor from the Taiwan cobra., Molecules 18, 8906-8918 (2013)

17. Hamatsu, J., O'Donovan, D., Tanaka, T., Shirai, T., Hourai, Y., Mikawa, T., Ikeya, T., Mishima, M., Boucher, W., Smith, B. O., Laue, E. D., Shirakawa, M. & *Ito, Y., High-resolution heteronuclear multidimensional NMR of proteins in living insect cells using a baculovirus protein expression system, J. Am. Chem. Soc. 135, 1688-1691 (2013)

18. Ikeya, T., Jee. J. G., Shigemitsu, Y., Hamatsu, J., Mishima, M., Ito, Y., Kainosho, M. & *Güntert, P. Exclusively NOESY-based automated NMR assignment and structure determination of proteins, J. Biomol. NMR.50, 137-146 (2011)

19. Ikeya, T., Sasaki, A., Sakakibara, D., Shigemitsu, Y., Hamatsu, J., Hanashima, T., Mishima, M., Yoshimasu, M., Hayashi, N., Mikawa, T., Nietlisbach, D., Wälchli, M., Smith, B. O., Shirakawa, M., Güntert, P. & *Ito, Y., NMR protein structure determination in living E. coli cells using nonlinear sampling. Nature Protocols 5, 1051-1060 (2010)

20. Sobhanifar, S., Schneider, B., Lohr, F., Gottstein, D., Ikeya, T., Filipek, S., Güntert, P., Bernhard, F. & *Dötsch, V., Structural investigation of the C-terminal catalytic fragment of presenilin-1. Proc. Natl. Acad. Sci. USA 107, 9644-9649 (2010)

21. Coutandin, D., Lohr, F., Niesen, F. H., Ikeya, T., Weber, T. A., Schafer, B., Bullock, A. N., Yang, A., Güntert, P. , Knapp, S., McKeon, F., Der Ou, H. & *Dötsch, V., Conformational stability and activity of p73 require a second helix in the tetramerization domain. Cell Death Diff. 16, 1582-1589 (2009)

22. Ikeya, T., Takeda, M., Yoshida, H., Terauchi, T., Jee, J., Kainosho, M. & Güntert, P., Automated NMR structure determination of stereo-array isotope labeled ubiquitin from minimal sets of spectra using the SAIL-FLYA system. J.Biomol.NMR. 44, 261-272 (2009)

23. ※Sakakibara, D., ※Sasaki, A., ※Ikeya, T., Hamatsu, J., Hanashima, T., Mishima, M., Yoshimasu, M., Hayashi, N., Mikawa, T., Wälchli, M., Smith,B.O., Shirakawa, M., Güntert, P. & *Ito, Y., Protein structure determination in living cells by in-cell NMR spectroscopy. Nature 458, 102-105 (2009)  
日本核磁気共鳴学会 (選挙管理委員会 2014-2015年度)
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