ABE Takuya
助教

阿部 拓也 アベ タクヤ あべ たくや

プロフィール

所属

東京都立大学理学部 化学科
理学研究科 化学専攻

最終学歴・学位

東北大学大学院薬学研究科生命薬学専攻・博士

専門・研究分野

生物化学

研究

研究テーマ

姉妹染色分体間接着の制御機構の解明

研究キーワード

コヒーシン DNA複製 DNA修復 DT40 

詳細情報

1, WRN counteracts the NHEJ pathway upon camptothecin exposure.
Otsuki M, Seki M, Kawabe Y, Inoue E, Dong YP, Abe T, Kato G, Yoshimura A, Tada S, Enomoto T.
Biochemical and Biophysical Researgh Communications 2007

2, Analyses of functional interaction between RECQL1, RECQL5, and BLM which physically interact with DNA topoisomerase IIIalpha.
Otsuki M, Seki M, Inoue E, Abe T, Narita Y, Yoshimura A, Tada S, Ishii Y, Enomoto T.
Biochimica et Biophysica Acta 2008

3, KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation.
Abe T, Ishiai M, Hosono Y, Yoshimura A, Tada S, Adachi N, Koyama H, Takata M, Takeda S, Enomoto T, Seki M.
Cellular Signalling 2008

4, Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD2.
Takada S, Inoue E, Tano K, Yoshii H, Abe T, Yoshimura A, Akita M, Tada S, Watanabe M, Seki M, Enomoto T.
Biochemical and Biophysical Researgh Communications 2009

5, A novel role for Rad17 in homologous recombination.
Nishino K, Inoue E, Takada S, Abe T, Akita M, Yoshimura A, Tada S, Kobayashi M, Yamamoto K, Seki M, Enomoto T.
Genes & Genetic Systems 2008

6, The N-terminal region of RECQL4 lacking the helicase domain is both essential and sufficient for the viability of vertebrate cells. Role of the N-terminal region of RECQL4 in cells.
Abe T, Yoshimura A, Hosono Y, Tada S, Seki M, Enomoto T.
Biochimica et Biophysica Acta 2011

7, The role of SNM1 family nucleases in etoposide-induced apoptosis.
Hosono Y, Abe T, Ishiai M, Takata M, Enomoto T, Seki M.
Biochemical and Biophysical Researgh Communications 2011
※Co-first author

8, The histone chaperone facilitates chromatin transcription (FACT) protein maintains normal replication fork rates.
Abe T, Sugimura K, Hosono Y, Takami Y, Akita M, Yoshimura A, Tada S, Nakayama T, Murofushi H, Okumura K, Takeda S, Horikoshi M, Seki M, Enomoto T.
The Journal of Biological Chemistry 2011

9, Functional relationship between Claspin and Rad17.
Yoshimura A, Akita M, Hosono Y, Abe T, Kobayashi M, Yamamoto K, Tada S, Seki M, Enomoto T.
Biochemical and Biophysical Researgh Communications 2011

10, The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment.
Era S, Abe T, Arakawa H, Kobayashi S, Szakal B, Yoshikawa Y, Motegi A, Takeda S, Branzei D. 
Biochemical and Biophysical Researgh Communications 2012

11, Tumor suppressor RecQL5 controls recombination induced by DNA crosslinking agents.
Hosono Y, Abe T, Ishiai M, Islam MN, Arakawa H, Wang W, Takeda S, Ishii Y, Takata M, Seki M, Enomoto T.
Biochim Biophys Acta. 2014

12, Tipin functions in the protection against topoisomerase I inhibitor.
Hosono Y, Abe T, Higuchi M, Kajii K, Sakuraba S, Tada S, Enomoto T, Seki M.
J Biol Chem. 2014
※Co-first author

13, High levels of BRC4 induced by a Tet-On 3G system suppress DNA repair and impair cell proliferation in vertebrate cells.
Abe T, and Branzei D.
DNA Repair (Amst). 2014
※Corresponding author

14, Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion.
Abe T, Kawasumi R, Arakawa H, Hori T, Shirahige K, Losada A, Fukagawa T, Branzei D.
Oncotarget. 7:67934-67947 (2016)

15, ESCO1/2's roles in chromosome structure and interphase chromatin organization.
Kawasumi R, Abe T, Arakawa H, Garre M, Hirota K, Branzei D.
Genes & Development 31: 2136-2150 (2017)(※Co-first author、Corresponding author)

16,Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites.
Abe T, Ooka M, Kawasumi R, Miyata K, Takata M, Hirota K, Branzei D.
Proceedings of the National Academy of Sciences of the United States of America 115:8412-8417 (2018)

17, AND-1 fork protection function prevents fork resection and is essential for proliferation.
Abe T, Kawasumi R, Giannattasio M, Dusi S, Yoshimoto Y, Miyata K, Umemura K, Hirota K, Branzei D.
Nature Communications 9:3091. (2018)
分子生物学会
  • 有機及生物化学演習
  • 有機及生物化学演習

連絡先

研究室

8号館449号室

内線番号

内線3535

メールアドレス

0330abe●tmu.ac.jp
(メールを送信される場合は●を@に変換してください)