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川原 裕之

氏 名川原 裕之カワハラ ヒロユキかわはら ひろゆき
職 位教授
所 属首都大学東京都市教養学部 理工学系 生命科学コース
理工学研究科 生命科学専攻
 
専門・研究分野細胞生物学・生化学・分子生物学
最終学歴・学位北海道大学大学院薬学研究科・博士(薬学)
研究テーマ細胞の増殖と分化を規定するタンパク質代謝システム
研究キーワードユビキチン・プロテアソーム・細胞増殖制御蛋白質・BAG6・Patched
研究業績・著書・
論文、その他
それに準じる業績
Minami, R., Hayakawa, A., Kagawa, H., Yanagi, Y., Yokosawa, H. and Kawahara, H. (2010) BAG-6 is essential for selective elimination of defective proteasomal substrates. J. Cell Biol. 190: 637-650.

Ojima, K., Y Kawabata, Y., Nakao, H., Nakao, K., Doi, N., Kitamura, F., Ono, Y., Hata, S., Suzuki, H., Kawahara, H., Labeit, S., Toyama-Sorimachi, N., Suzuki, K., Maeda, T., Abe, K., Aiba, A., and Sorimachi, H. (2010) Role of dynamic distribution of muscle-specific calpain in physical-stress adaptation and muscular dystrophy in mice. J. Clinc. Invest. 120: 2672-2683.

Endo, R., Saito, T., Asada, A., Kawahara, H. and Hisanaga, S.-I. (2009) Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 Cyclin-dependent kinase 5 activator. J. Biol. Chem. 284, 26029-26039.

Minami, R., Shimada, M., Yokosawa, H. and Kawahara, H. (2007) Scythe regulates apoptosis through modulating ubiquitin-mediated proteolysis of XEF1AO. Biochem. J. (London) 405: 495-501.

Hamazaki, J., Sasaki, K., Kawahara, H., Hisanaga, S., Tanaka, K., and Murata, S. (2007) Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development. Mol. Cell. Biol. 27: 5529-6638.

Tayama, Y., Kawahara, H., Minami, R., Shimada, M., and Yokosawa, H. (2007) Association of Rpn10 with high molecular weight complex is enhanced during retinoic acid-induced differentiation of neuroblastoma cells. Mol. Cell. Biochem.

Shimada, M., Kanematsu, K., Tanaka, K., Yokosawa, H. and Kawahara, H. (2006) Proteasomal ubiquitin receptor RPN-10 controls sex determination in Caenorhabditis elegans. Mol. Biol. Cell 17: 5356-5371.

Shimada, M., Yokosawa, H., and Kawahara, H. (2006) OMA-1 is a P granules-associated protein that is required for germline specification in C. elegans. Genes Cells 11, 383-396.

Hata, S., Koyama, S., Kawahara, H., Doi, N., Maeda, T., Toyama-Sorimachi, N., Abe, K., Suzuki, K., and Sorimachi, H. (2006) Stomach-specific calpain localizes in mucus cells and proteolyses the β-subunit of coatomer complex, β-COP. J. Biol. Chem. 281, 11214-11224.

Kikukawa, Y., Minami, R., Shimada, M., Kobayashi, M., Tanaka, K., Yokosawa, H., and Kawahara, H. (2005) Unique proteasome subunit Xrpn10c is a specific receptor for the antiapoptotic ubiquitin-like protein Scythe. FEBS J. 272, 6373-6386.

Saeki, Y., Isono, E., Shimada, M., Kawahara, H., Yokosawa, H., and Toh-e, A. (2005) Knocking out ubiquitin proteasome system function in vivo and in vitro with genetically-encodable tandem ubiquitin. Methods Enzymol. 399, 64-74.

Kinouchi, T., Ishiura, S., Mabuchi, Y., Urakami-Manaka, Y., Nishio, H., Nishiuchi, Y., Tsunemi, M., Takada, K., Watanabe, M., Ikeda, M., Matsui, H., Tomioka, S., Kawahara, H., Hamamoto, T., Suzuki, K., Kagawa, Y. (2004) Mammalian D-aspartyl endopeptidase: a scavenger for noxious racemized proteins in aging. Biochem. Biophys. Res. Comm. 314, 730-736.

Tsukamoto, S., Yamashita, K., Tane, K., Kizu, R., Ohta, T., Matsunaga, S., Fusetani, N., Kawahara, H., and Yokosawa, H. (2004) Girolline, an antitumor compound isolated from a sponge, induces G2/M cell cycle arrest and accumulation of polyubiquitinated p53. Biol. Pharm. Bull. 27, 699-701.

Saeki, Y., Isono, E., Oguchi, T., Shimada, M., Sone, T., Kawahara, H., Yokosawa, H., and Toh-e, A. (2004) Intracellularly inducible, ubiquitin hydrolase-insensitive tandem ubiquitins inhibit the 26S proteasome activity and cell division. Genes Genet. Syst. 79, 77-86.

Sakata, E., Yamaguchi, Y., Kurimoto, E., Kikuchi, J., Yokoyama, S., Yamada, S., Kawahara, H., Yokosawa, H., Hattori, N., Mizuno, Y., Tanaka, K. and Kato. K. (2003) Parkin binds the Rpn10 subunit of the 26S proteasome with the ubiquitin-like domain. EMBO Rep. 4, 301-306.

Sato, N., Kawahara, H., Toh-e, A. and Maeda, T. (2003) Phosphorelay-regulated degradation of the yeast Ssk1p response regulator by the ubiquitin-proteasome system. Mol. Cell. Biol. 23, 6662-6671.

Kawai, N., Shimada, M., Kawahara, H., Satoh, N. and Yokosawa, H. (2003) Regulation of ascidian Rel by its alternative splice variant. Eur. J. Biochem. 270, 4459-4468.

Shimada, M., Kawahara, H., and Doi, H. (2002) Novel family of CCCH type Zinc-finger proteins; MOE-1, -2 , and -3, participate in C. elegans oocyte maturation. Genes Cells 7, 933-947.

Kikukawa, Y., Shimada, M., Suzuki, N., Tanaka, K., Yokosawa, H., and Kawahara, H. (2002) The 26S proteasome rpn10 gene encoding splicing isoforms: evolutional conservation of the genomic organization in vertebrates. Biol. Chem. 383, 1257-1261.

Takahashi, N., Sasagawa, N., Usuki, F., Kino, Y., Kawahara, H., Sorimachi, H., Maeda, T., Suzuki, K., and Ishiura, S. (2001) Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS cells. J. Biochem. 130, 581-587.

Umeda, T., Kouchi, Z., Kawahara, H., Tomioka, S., Sasagawa, N.,Maeda, T., Sorimachi, H., Ishiura, S., and Suzuki, K. (2001) Limited proteolysis of filamin is catalyzed by caspase-3 in U937 and Jurkat cells. J. Biochem. 130, 535-542.

Hata, S., Nishi, K., Kawamoto, T., Lee, H.J., Kawahara, H., Maeda, T., Sorimachi, H., Suzuki, K. (2001) Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution. J. Mol. Evol. 53, 191-203.

Kawahara, H., Philipova, R., Yokosawa, H., Patel, R., Tanaka, K. and Whitaker, M. (2000) Inhibiting proteasome activity causes over-replication of DNA and blocks entry into mitosis in sea urchin embryos. J. Cell Sci. 113, 2659-2670.

Kawahara, H., Kasahara, M., Nishiyama, A., Ohsumi, K., Goto, T., Kishimoto, T., Saeki, Y., Yokosawa, H., Shimbara, N., Mutrata, S., Chiba, T., Suzuki, K. and Tanaka, K. (2000) Developmentally regulated alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes. EMBO J. 19, 4144-4153.

Murata, S., Kawahara, H., Tohma, S., Kasahara, K., Tanaka, K. and Chiba, T. (1999) Growth retardation of mice lacking the proteasome activator PA28 γ. J. Biol. Chem. 274, 38211-38215.

嶋田益弥、川原裕之(2010)「卵成熟制御におけるCCCH型zinc-finger蛋白質の機能」「細胞周期フロンティア」共立出版

川原裕之, 嶋田益弥, 南亮介, 横沢英良 (2006)「ユビキチンレセプターの構造と機能」蛋白質核酸酵素, 増刊号pp.1245-1250,共立出版

佐伯泰, 川原裕之, 横沢英良 (2003)「ユビキチンと相互作用するドメイン構造」実験医学、21, 340-345, 羊土社
受 賞
主な学会活動日本生化学会・日本分子生物学会・日本癌学会・日本発生生物学会・
The American Society for Cell Biology
社会等との関わり文部科学省科学研究費特定領域研究計画班員
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担当科目
  • バイオテクノロジー
  • 人間生物学a
  • 生体情報学各論(細胞機能の調節機構)
  • 分子生物学実験(細胞生化学)
  • 生化学特論
  • 生化学特論
  • 生命科学セミナー1(細胞生化学1)
  • 生命科学セミナー1(細胞生化学1)
  • 生命科学セミナー2(細胞生化学1)
  • 生命科学セミナー2(細胞生化学1)
  • 生命科学セミナー1(細胞生化学2)
  • 生命科学セミナー1(細胞生化学2)
  • 生命科学セミナー2(細胞生化学2)
  • 生命科学セミナー2(細胞生化学2)
  • 生命科学実験1(細胞生化学)
  • 生命科学実験1(細胞生化学)
  • 生命科学実験2(細胞生化学)
  • 生命科学実験2(細胞生化学)
  • バイオテクノロジー
  • 人間生物学a
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