本文へ移動します

安藤 香奈絵

氏 名安藤 香奈絵アンドウ カナエあんどう かなえ
職 位准教授
所 属首都大学東京都市教養学部 理工学系 生命科学コース
理工学研究科 生命科学専攻
 
専門・研究分野Neuroscience, Cell Biology, Molecular Biology
最終学歴・学位Ph.D., 2001, University of Tokyo
研究テーマMechanisms underlying mitochondrial distribution in the axon and neurodegeneration caused by loss of axonal mitochondria
研究キーワードNeurobiology, mitochondria, Alzheimer's disease, tau, drosophila model of disease
研究業績・著書・
論文、その他
それに準じる業績
*Ando, K., Oka, M., Ohtake, Y., Hayashishita, M., Shimizu, S., Hisanaga, S., and Iijima, K.M.* Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated. Biochemical and Biophysical Research Communications, Volume 478, Issue 2, Pages 929?934(2016)

*Ando, K., Maruko-Otake, A., Ohtake, Y., Hayashishita, M., Sekiya, M., and Iijima, K. M*. Stabilization of microtubule-unbound tau via tau phosphorylation at Ser262/356 by Par-1/MARK contributes to augmentation of AD-related phosphorylation and Aβ42-induced tau toxicity. PLoS Genetics 12(3): e1005917, 2016.

Electron microscopy of the brains of Drosophila Models of Alzheimer’s disease. Ando, K*., Hearn, A., Suzuki, E., Maruko-Otake, A., Sekiya, M., and Iijima, M.K*.  Neuromethods, Springer, Humana Press, in press (2015).

Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2.
Mendoza, J., Sekiya, M., Taniguchi, T., Iijima, K. M., Wang, R*. and Ando, K*.
Journal of Proteome Research. 2013 Jun 7;12(6):2654-65. doi: 10.1021/pr400008f.

Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer’s disease-related tau phosphorylation via PAR-1
Iijima-Ando, K.*, Sekiya, M., Maruko-Otake, A., Ohtake, Y., Suzuki, E., Lu, B. & Iijima, K. M.* 
PLoS Genetics Aug;8(8):e1002918. Epub 2012 Aug 30.

Matsushima, T., Saito, Y., Elliott, J. I., Iijima-Ando, K., Nishimura, M., Kimura, N., Hata, S., Yamamoto, Y., Nakaya, T., and Suzuki, T
Membrane microdomain localization of APP C-terminal fragments regulated by the phosphorylation at cytoplasmic Thr668 residue. J Biol Chem, 287(23):19715-24. (2012)

Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer’s disease.
Iijima, K.*, Gatt, A., and Iijima-Ando, K.*
Hum Mol Genet. Aug 1;19(15):2947-57. (2010)

A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration. Iijima-Ando, K.*, Zhao, L., Gatt, A., Shenton, C., and Iijima, K.*  
Hum Mol Genet. May 15;19(10):1930-8. (2010)

Transgenic Drosophila models of Alzheimer’s disease and tauopathies. (Review).
Iijima-Ando*, K and Iijima*, K.
Brain Structure & Function, 214(2-3):245-62. (2009)

Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila.
Iijima, K*, Zhao, L., Shenton, C., and Iijima-Ando, K.*
PLoS ONE 4(12): e8498.(2009)

Mitochondrial Mislocalization Underlies Aβ42-Induced Neuronal Dysfunction in a Drosophila Model of Alzheimer’s Disease. Iijima-Ando*, K., Hearn, S. A., Shenton, C., Gatt, A., Zhao, L., and Iijima, K*.
PLoS ONE 4(12): e8310 (2009)

JNK/FOXO-mediated neuronal expression of fly homologue of Peroxiredoxin II reduces oxidative stress and extends lifespan in Drosophila.
Lee, K-S., Iijima-Ando, K., Iijima, K., Lee, W-J., Lee, J.H., Yu, K., and Lee, D-S.
J Biol Chem, 284(43):29454-61 (2009)

Drosophila models of Alzheimer’s amyloidosis; the challenge of dissecting the complex mechanisms of toxicity of amyloid-β 42. (Review)
Iijima, K.* and Iijima-Ando, K.*
Journal of Alzheimer's Disease, 2008, Dec;15(4):523-40. (2008)

Overexpression of Neprilysin Reduces Alzheimer Amyloid β 42 (Aβ42)-induced Neuron Loss and Intraneuronal Aβ42 Deposits but Causes a Reduction in cAMP-responsive Element-binding Protein-mediated Transcription, Age-dependent Axon Pathology, and Premature Death in Drosophila. Iijima-Ando, K.*, Hearn, S.A., Granger, L., Shenton, C., Gatt, A., Chiang, H.C., Hakker, I., Zhong, Y., and Iijima, K.*
J Biol Chem 283, 19066-19076. (2008)

Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila. Iijima, K., Chiang, H. C., Hearn, S. A., Hakker, I., Gatt, A., Shenton, C., Granger, L., Leung, A., Iijima-Ando, K., and Zhong, Y.
PLoS ONE 3, e1703 (2008)

Physiological mouse brain amyloid-beta levels are not related to the phosphorylation state of threonine-668 of Alzheimer’s APP.
Sano, Y., Nakaya, T., Pedrini, S., Furukori, K., Iijima-Ando, K., Iijima, K., Mathews, P.M., Itohara, S., Gandy, S, and Suzuki, T.
PLoS ONE, 1, e51. (2006)

cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila. Iijima-Ando, K.*, Wu, P., Drier, E. A., Iijima, K., and Yin, J. C.* (* Corresponding authors)
Proc Natl Acad Sci U S A 102, 10261-10266. (2005)

Asaumi, M., Iijima, K., Sumioka, A., Iijima-Ando, K., Kirino, Y., Nakaya, T., Suzuki, T. (2005)
Interaction of N-Terminal Acetyltransferase with the Cytoplasmic Domain of β-Amyloid Precursor Protein and Its Effect on Aβ Secretion. J. Biochem. 137(2):147-55.

Ando, K., Iijima, K., Elliott, J. I., Kirino, Y. and Suzuki, T. (2001) Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of β-amyloid. J Biol Chem, 276,40353-61

Iijima, K., Ando, K., Takeda, S., Satoh, Y., Seki, T., Itohara, S., Greengard, P., Narin, A. C., Kirino, Y., and Suzuki, T. (2000) Neuron-specific phosphorylation of Alzheimer's precursor protein by Cdk5. J Neurochem 75, 1085-91.

Ando, K., Oishi, M., Takeda, S., Iijima, K., Isohara, T., Nairn, A. C., Kirino, Y., Greengard, P., and Suzuki, T. (1999) Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation. J Neurosci 19, 4421-7.

Isohara, T., Horiuchi, A., Watanabe, T., Ando, K., Czernik, A. J., Uno, I., Greengard, P., Nairn, A. C., and Suzuki, T. (1999). Phosphorylation of the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein at Ser655 by a novel protein kinase. Biochem Biophys Res Commun 258, 300-5.

Suzuki, T., Ando, K., Isohara, T., Oishi, M., Lim, G. S., Satoh, Y., Wasco, W., Tanzi, R. E., Nairn, A. C., Greengard, P., Gandy, S. E., and Kirino, Y. (1997). Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. Biochemistry 36, 4643-9.
受 賞1996-1998 Scholarship from the Japan Scholarship Foundation
1998-2001 Japan Society for the Promotion of Science (JPSP) Research Fellowships for Young Scientists
2002-2005 Human Frontier Science Program Long Term Fellowships
2005-2006 Postdoctoral fellowship from Hereditary Disease Foundation
2010-2011 Jefferson Intramural Pilot Research Award
2010-2012 New Investigator Research Grant Award in Alzheimer’s Association
主な学会活動Society for Neuroscience (member, 2004-)
社会等との関わり
個人のURL
担当科目
  • 基礎ゼミナール
  • 人間生物学b
  • 生化学実験(神経分子機能)
  • General Biochemistry 2(生化学概論2)
  • General Genetics 1(遺伝学概論1)
  • General Physiology(生理学概論)
  • Neuroscience(神経科学各論)
  • Special Lecture in Biology(生物学特別講義)
  • Special Lecture in Biology(生物学特別講義)
  • 生命科学セミナー1(神経分子機能1)
  • 生命科学セミナー1(神経分子機能1)
  • 生命科学セミナー2(神経分子機能1)
  • 生命科学セミナー2(神経分子機能1)
  • 生命科学セミナー1(神経分子機能2)
  • 生命科学セミナー1(神経分子機能2)
  • 生命科学セミナー2(神経分子機能2)
  • 生命科学セミナー2(神経分子機能2)
  • 生命科学セミナー1(神経分子機能3)
  • 生命科学セミナー1(神経分子機能3)
  • 生命科学セミナー2(神経分子機能3)
  • 生命科学セミナー2(神経分子機能3)
  • 生命科学セミナー1(神経分子機能4)
  • 生命科学セミナー1(神経分子機能4)
  • 生命科学セミナー2(神経分子機能4)
  • 生命科学セミナー2(神経分子機能4)
  • 生命科学実験1(神経分子機能)
  • 生命科学実験1(神経分子機能)
  • 生命科学実験2(神経分子機能)
  • 生命科学実験2(神経分子機能)
  • 人間生物学b
オフィスアワーWednesday 16:20-17:50
研究室Office: 8-324
Lab: 9-493
内線番号内線3663
メールアドレス変換画像
(メールを送信される場合は●を@に変換してください)
研究室サイト等
取組状況
researchmap
取組成果
ページトップへ